Biologic Therapies for Aging Discs Bethany OK

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Harvey C Jenkins Jr., MD
(405) 686-1700
8603 S Western Ave
Oklahoma City, OK
Business
Aria Orthopedics
Specialties
Orthopedics

Data Provided By:
Jerald Milton Gilbert, MD
7530 NW 23rd St
Bethany, OK
Specialties
Orthopedics, Hand Surgery
Gender
Male
Education
Medical School: Univ Of Ok Coll Of Med, Oklahoma City Ok 73190
Graduation Year: 1975

Data Provided By:
Amy Lynn Counts, DDS
(405) 271-6087
1001 Stanton L Young Bl # 494
Oklahoma City, OK
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Jason C Emerson, DO
Oklahoma City, OK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Ok State Univ, Coll Of Osteo Med, Tulsa, Ok 74107
Graduation Year: 2001

Data Provided By:
Gary B Anderson
(405) 947-0911
3301 N.W. 50th St
Oklahoma City, OK
Specialty
Orthopedic Surgery

Data Provided By:
Jack William Balenseifen, DDS
(405) 789-6772
7505 Nw 23Rd St
Bethany, OK
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Christopher Lee Peters, MD
(405) 440-9689
2916 N McMillan Ave
Bethany, OK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Southern Ca Sch Of Med, Los Angeles Ca 90033
Graduation Year: 1988

Data Provided By:
Kenneth William Jackson, MD
(703) 383-5400
7301 N Comanche Ave
Warr Acres, OK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Umdnj-New Jersey Med Sch, Newark Nj 07103
Graduation Year: 1979

Data Provided By:
Jason C Emerson, DO
(405) 209-8932
3404 NW 20th St
Oklahoma City, OK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Ok State Univ, Coll Of Osteo Med, Tulsa, Ok 74107
Graduation Year: 2001

Data Provided By:
Gary B Anderson, MD
(405) 947-0911
3301 NW 50th St
Oklahoma City, OK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Oh State Univ Coll Of Med, Columbus Oh 43210
Graduation Year: 1989
Hospital
Hospital: Bone & Joint Hosp, Oklahoma City, Ok; Integris Baptist Med Ctr, Oklahoma City, Ok; Deaconess Hosp, Oklahoma City, Ok; Northwest Surgical Hospital, Oklahoma City, Ok
Group Practice: Orthopedic Associates

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Biologic Therapies for Aging Discs

The lines and wrinkles on our faces aren't the only signs of the inevitable aging process. Progressive degenerative changes have also been documented in the spine. One of the areas of great interest is the intervertebral disc . New biologic therapies for aging discs are the subject of this review article on the topic.

There are 33 vertebrae or spinal bones. Between each vertebra is a disc made of tough cartilage with a fluid center. These discs provide the cushion that allows your backbone to bend and twist. Discs also act like shock absorbers as we walk, run, and jump. Each vertebral segment consists of bone next to bone with a cartilage cushion between. They are tied together with connective tissue, ligaments, and tendons.

Degenerative disc disease is an example of something that affects most people as they get older. Everyone is going to have a certain amount of damage to the spine. This occurs throughout a lifetime. The discs can flatten, and protrude from between the bones. In time, most people will have small tears in the outer layers of these discs.

Finding ways to repair damage to the discs is the focus of many research studies. One of the most recent directions in research has been the use of biologic therapies to restore the disc. Examples of these treatment approaches include disc cell reimplantation, stem cell implantation, disc denervation, injection of therapeutic proteins, and gene therapy.

What are these therapies and how do they work? Biologic therapies of this type are meant to help at the cellular level. Scientists have shown that inside the cells of the disc there is a limited amount of blood flow. As a result, there are waste products building up. The cell becomes very acidic and that is a harsh environment that doesn't support cell health very well.

As we age, there are fewer new cells to replace the old. Fluid leaks out of the discs that never gets replaced. We start to lose the strength of the discs needed to cushion and support the spine. A loss of disc height can lead to disc space collapse.

That's what's happening on the inside at the cellular level. On the outside, the affected individual may not feel anything until the degenerative process has gone on quite a while. Eventually, back pain, loss of motion, and loss of function get our attention. By then, there may not be much that can be done to save the disc. Right now, surgery to remove the disc is often the only option.

That could change if any of these biologic therapies can be perfected. Right now they are still in the experimental stages. Most of the studies have been done on animals but a few human trials have been conducted.

For example, disc tissue reimplantation is a process in which a few healthy cells are removed from an intact disc. They are taken to a lab where they can be multiplied and then reinjected into the diseased disc. The hope is that the new, healthy cells will replace the damaged cells and restore the strength of t...

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