Biologic Therapies for Aging Discs Branson MO

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Darin L Talley
(417) 334-8877
511 Bee Creek Rd
Branson, MO
Specialty
Orthopedic Surgery

Data Provided By:
Darin L Talley, MD
(417) 334-8877
511 Bee Creek Rd
Branson, MO
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Tx Med Sch At San Antonio, San Antonio Tx 78284
Graduation Year: 1996

Data Provided By:
Lawrence V Page
(417) 348-8100
121 Cahill Rd
Branson, MO
Specialty
Orthopedic Surgery

Data Provided By:
J Marcus Heim, DO
(573) 348-4432
590 Birch Rd
Hollister, MO
Specialties
Orthopedics
Gender
Male
Education
Medical School: Ok State Univ, Coll Of Osteo Med, Tulsa, Ok 74107
Graduation Year: 1982
Hospital
Hospital: Breech Med Ctr, Lebanon, Mo
Group Practice: Lake Orthopedic Group

Data Provided By:
Thomas J Banton, MD
Saint Louis, MO
Specialties
Orthopedics
Gender
Male
Education
Graduation Year: 2007

Data Provided By:
John W Huffman, DO
(850) 651-5034
511 Bee Creek Rd
Branson, MO
Specialties
Orthopedics
Gender
Male
Education
Medical School: Kirksville Coll Of Osteo Med, Kirksville Mo 63501
Graduation Year: 1985

Data Provided By:
Robert Patrick O'Brien
(417) 334-8877
511 Bee Creek Rd
Branson, MO
Specialty
Orthopedic Surgery

Data Provided By:
Robert Patrick O'Brien, MD
(417) 334-8877
511 Bee Creek Rd
Branson, MO
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Az Coll Of Med, Tucson Az 85724
Graduation Year: 1975

Data Provided By:
Robert A Shively, MD
(314) 652-4100
915 N Grand Ave
Saint Louis, MO
Business
Washington University Orthopedics
Specialties
Orthopedics

Data Provided By:
Kurt Dwight Merkel, MD
(314) 989-1091
Missouri Baptist Med Ctr 3009 N Ballas Rd Ste 243A
Saint Louis, MO
Specialties
Orthopedics, Musculoskeletal Oncology
Gender
Male
Education
Medical School: St Louis Univ Sch Of Med, St Louis Mo 63104
Graduation Year: 1980
Hospital
Hospital: Depaul Health Center, Bridgeton, Mo; St Louis University Hlth Scien, Saint Louis, Mo; Des Peres, Saint Louis, Mo; Missouri Baptist Med Ctr, Saint Louis, Mo; St Joseph Hospital West, Lake St Louis, Mo
Group Practice: Town & Country Orthopedics

Data Provided By:
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Biologic Therapies for Aging Discs

The lines and wrinkles on our faces aren't the only signs of the inevitable aging process. Progressive degenerative changes have also been documented in the spine. One of the areas of great interest is the intervertebral disc . New biologic therapies for aging discs are the subject of this review article on the topic.

There are 33 vertebrae or spinal bones. Between each vertebra is a disc made of tough cartilage with a fluid center. These discs provide the cushion that allows your backbone to bend and twist. Discs also act like shock absorbers as we walk, run, and jump. Each vertebral segment consists of bone next to bone with a cartilage cushion between. They are tied together with connective tissue, ligaments, and tendons.

Degenerative disc disease is an example of something that affects most people as they get older. Everyone is going to have a certain amount of damage to the spine. This occurs throughout a lifetime. The discs can flatten, and protrude from between the bones. In time, most people will have small tears in the outer layers of these discs.

Finding ways to repair damage to the discs is the focus of many research studies. One of the most recent directions in research has been the use of biologic therapies to restore the disc. Examples of these treatment approaches include disc cell reimplantation, stem cell implantation, disc denervation, injection of therapeutic proteins, and gene therapy.

What are these therapies and how do they work? Biologic therapies of this type are meant to help at the cellular level. Scientists have shown that inside the cells of the disc there is a limited amount of blood flow. As a result, there are waste products building up. The cell becomes very acidic and that is a harsh environment that doesn't support cell health very well.

As we age, there are fewer new cells to replace the old. Fluid leaks out of the discs that never gets replaced. We start to lose the strength of the discs needed to cushion and support the spine. A loss of disc height can lead to disc space collapse.

That's what's happening on the inside at the cellular level. On the outside, the affected individual may not feel anything until the degenerative process has gone on quite a while. Eventually, back pain, loss of motion, and loss of function get our attention. By then, there may not be much that can be done to save the disc. Right now, surgery to remove the disc is often the only option.

That could change if any of these biologic therapies can be perfected. Right now they are still in the experimental stages. Most of the studies have been done on animals but a few human trials have been conducted.

For example, disc tissue reimplantation is a process in which a few healthy cells are removed from an intact disc. They are taken to a lab where they can be multiplied and then reinjected into the diseased disc. The hope is that the new, healthy cells will replace the damaged cells and restore the strength of t...

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