Biologic Therapies for Aging Discs Clarksburg WV

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Matthew Philip Darmelio, MD
(304) 624-6000
300 Davisson Run Rd Ste 301
Clarksburg, WV
Specialties
Orthopedics
Gender
Male
Education
Medical School: Wv Univ Sch Of Med, Morgantown Wv 26506
Graduation Year: 1994
Hospital
Hospital: United Hospital Center, Clarksburg, Wv; Grafton City Hospital, Grafton, Wv

Data Provided By:
Charles Armand Lefebure, MD
(304) 624-7421
4 Hospital Plz
Clarksburg, WV
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Ottawa, Fac Of Med, Ottawa, Ont, Canada
Graduation Year: 1970

Data Provided By:
Charles A Lefebure
(304) 624-7421
4 Hospital Plaza
Clarksburg, WV
Specialty
Orthopedic Surgery

Data Provided By:
Thomas Campbell Kennedy, MD
(509) 454-8888
4 Hospital Plz
Clarksburg, WV
Specialties
Orthopedics
Gender
Male
Education
Medical School: Washington Univ Sch Of Med, St Louis Mo 63110
Graduation Year: 1984

Data Provided By:
Dr.George Bal
(304) 598-4800
527 Medical Park Dr
Bridgeport, WV
Gender
M
Speciality
Orthopedic Surgeon
General Information
Accepting New Patients: Yes
RateMD Rating
5.0, out of 5 based on 5, reviews.

Data Provided By:
David Lee Waxman, MD
(304) 341-1500
600 Davisson Run Rd
Clarksburg, WV
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Md Sch Of Med, Baltimore Md 21201
Graduation Year: 1982
Hospital
Hospital: United Hospital Center, Clarksburg, Wv
Group Practice: University Health Associates

Data Provided By:
David L Waxman
(304) 623-5000
600 Davisson Run Rd
Clarksburg, WV
Specialty
Orthopedic Surgery, Adult Reconstructive Orthopaedic Surgery

Data Provided By:
Dr.Doyle Sickles
(304) 624-6000
300 Davisson Run Road #302
Clarksburg, WV
Gender
M
Education
Medical School: Wv Univ Sch Of Med
Year of Graduation: 1979
Speciality
Orthopedic Surgeon
General Information
Hospital: United Hospital Center, Clarksburg, Wv
Accepting New Patients: Yes
RateMD Rating
5.0, out of 5 based on 1, reviews.

Data Provided By:
Doyle Russell Sickles, MD
(304) 624-6000
300 Davisson Run Rd
Clarksburg, WV
Specialties
Orthopedics
Gender
Male
Education
Medical School: Wv Univ Sch Of Med, Morgantown Wv 26506
Graduation Year: 1979
Hospital
Hospital: United Hospital Center, Clarksburg, Wv
Group Practice: University Health Associates

Data Provided By:
Jack S Koay, MD
(304) 366-6511
19 Oakwood Rd
Fairmont, WV
Specialties
Orthopedics, Hand Surgery
Gender
Male
Education
Medical School: Coll Of Med Natl Taiwan Univ, Taipei, Taiwan (244-02 Eff 1/1971)
Graduation Year: 1964
Hospital
Hospital: Fairmont Gen Hosp, Fairmont, Wv
Group Practice: Jack S Koay Inc

Data Provided By:
Data Provided By:

Biologic Therapies for Aging Discs

The lines and wrinkles on our faces aren't the only signs of the inevitable aging process. Progressive degenerative changes have also been documented in the spine. One of the areas of great interest is the intervertebral disc . New biologic therapies for aging discs are the subject of this review article on the topic.

There are 33 vertebrae or spinal bones. Between each vertebra is a disc made of tough cartilage with a fluid center. These discs provide the cushion that allows your backbone to bend and twist. Discs also act like shock absorbers as we walk, run, and jump. Each vertebral segment consists of bone next to bone with a cartilage cushion between. They are tied together with connective tissue, ligaments, and tendons.

Degenerative disc disease is an example of something that affects most people as they get older. Everyone is going to have a certain amount of damage to the spine. This occurs throughout a lifetime. The discs can flatten, and protrude from between the bones. In time, most people will have small tears in the outer layers of these discs.

Finding ways to repair damage to the discs is the focus of many research studies. One of the most recent directions in research has been the use of biologic therapies to restore the disc. Examples of these treatment approaches include disc cell reimplantation, stem cell implantation, disc denervation, injection of therapeutic proteins, and gene therapy.

What are these therapies and how do they work? Biologic therapies of this type are meant to help at the cellular level. Scientists have shown that inside the cells of the disc there is a limited amount of blood flow. As a result, there are waste products building up. The cell becomes very acidic and that is a harsh environment that doesn't support cell health very well.

As we age, there are fewer new cells to replace the old. Fluid leaks out of the discs that never gets replaced. We start to lose the strength of the discs needed to cushion and support the spine. A loss of disc height can lead to disc space collapse.

That's what's happening on the inside at the cellular level. On the outside, the affected individual may not feel anything until the degenerative process has gone on quite a while. Eventually, back pain, loss of motion, and loss of function get our attention. By then, there may not be much that can be done to save the disc. Right now, surgery to remove the disc is often the only option.

That could change if any of these biologic therapies can be perfected. Right now they are still in the experimental stages. Most of the studies have been done on animals but a few human trials have been conducted.

For example, disc tissue reimplantation is a process in which a few healthy cells are removed from an intact disc. They are taken to a lab where they can be multiplied and then reinjected into the diseased disc. The hope is that the new, healthy cells will replace the damaged cells and restore the strength of t...

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