Biologic Therapies for Aging Discs Kihei HI

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Michael Siaw, MD
(931) 433-5501
1032 S Kihei Rd
Kihei, HI
Specialties
Orthopedics
Gender
Male
Education
Medical School: Loma Linda Univ Sch Of Med, Loma Linda Ca 92350
Graduation Year: 1964

Data Provided By:
C E Probst, MD
(808) 243-6510
17085 Haleakala Hwy
Kula, HI
Specialties
Orthopedics
Gender
Male
Education
Medical School: Jefferson Med Coll-Thos Jefferson Univ, Philadelphia Pa 19107
Graduation Year: 1968

Data Provided By:
Peter Conmy, DDS
(808) 873-8199
285 W Kaahumanu Ave Ste 220
Kahului, HI
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Charles Bedell, DDS
(808) 871-6576
Kahului Ofc Ctr Ste 312 140 Hoohana St
Kahului, HI
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Marvin Mitsuo Tanaka, DDS
(808) 242-9062
1703 Wili Pa Loop Ste 200
Wailuku, HI
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Tetsuto Numata, MD
(808) 871-0778
PO Box 1091
Kihei, HI
Specialties
Orthopedics
Gender
Male
Education
Medical School: Harvard Med Sch, Boston Ma 02115
Graduation Year: 1979
Hospital
Hospital: Winchester Hospital, Winchester, Ma; Hallmark Health -Medford Lawr, Medford, Ma

Data Provided By:
Tetsuto Numata
(808) 871-0778
140 Hoohana St
Kahului, HI
Specialty
Orthopedic Surgery

Data Provided By:
Robert S Harvey
(808) 871-8410
53 S Puunene Ave
Kahului, HI
Specialty
Orthopedic Surgery

Data Provided By:
Dr.Darren Egami
(808) 244-7199
2200 Main Street #300
Wailuku, HI
Gender
M
Education
Medical School: Univ Of Hi John A Burns Sch Of Med
Year of Graduation: 1993
Speciality
Orthopedic Surgeon
General Information
Accepting New Patients: Yes
RateMD Rating
3.6, out of 5 based on 5, reviews.

Data Provided By:
Jonothan L Miller
(808) 243-6000
80 Mahalani St
Wailuku, HI
Specialty
Orthopedic Surgery

Data Provided By:
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Biologic Therapies for Aging Discs

The lines and wrinkles on our faces aren't the only signs of the inevitable aging process. Progressive degenerative changes have also been documented in the spine. One of the areas of great interest is the intervertebral disc . New biologic therapies for aging discs are the subject of this review article on the topic.

There are 33 vertebrae or spinal bones. Between each vertebra is a disc made of tough cartilage with a fluid center. These discs provide the cushion that allows your backbone to bend and twist. Discs also act like shock absorbers as we walk, run, and jump. Each vertebral segment consists of bone next to bone with a cartilage cushion between. They are tied together with connective tissue, ligaments, and tendons.

Degenerative disc disease is an example of something that affects most people as they get older. Everyone is going to have a certain amount of damage to the spine. This occurs throughout a lifetime. The discs can flatten, and protrude from between the bones. In time, most people will have small tears in the outer layers of these discs.

Finding ways to repair damage to the discs is the focus of many research studies. One of the most recent directions in research has been the use of biologic therapies to restore the disc. Examples of these treatment approaches include disc cell reimplantation, stem cell implantation, disc denervation, injection of therapeutic proteins, and gene therapy.

What are these therapies and how do they work? Biologic therapies of this type are meant to help at the cellular level. Scientists have shown that inside the cells of the disc there is a limited amount of blood flow. As a result, there are waste products building up. The cell becomes very acidic and that is a harsh environment that doesn't support cell health very well.

As we age, there are fewer new cells to replace the old. Fluid leaks out of the discs that never gets replaced. We start to lose the strength of the discs needed to cushion and support the spine. A loss of disc height can lead to disc space collapse.

That's what's happening on the inside at the cellular level. On the outside, the affected individual may not feel anything until the degenerative process has gone on quite a while. Eventually, back pain, loss of motion, and loss of function get our attention. By then, there may not be much that can be done to save the disc. Right now, surgery to remove the disc is often the only option.

That could change if any of these biologic therapies can be perfected. Right now they are still in the experimental stages. Most of the studies have been done on animals but a few human trials have been conducted.

For example, disc tissue reimplantation is a process in which a few healthy cells are removed from an intact disc. They are taken to a lab where they can be multiplied and then reinjected into the diseased disc. The hope is that the new, healthy cells will replace the damaged cells and restore the strength of t...

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