Biologic Therapies for Aging Discs Newark DE

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David T Sowa, MD
(302) 731-2888
4745 Ogletown Stanton Rd
Newark, DE
Business
First State Orthopaedics PA
Specialties
Orthopedics

Data Provided By:
Robert A Steele
(302) 731-2888
4745 Ogletown Stanton Rd
Newark, DE
Specialty
Orthopedic Surgery, Foot & Ankle Surgery

Data Provided By:
Randeep Singh Kahlon, MD
(302) 731-2888
Suite 225 4745 Stanton-Ogletown Rd
Newark, DE
Specialties
Orthopedics, Hand Surgery
Gender
Male
Education
Medical School: Umdnj-New Jersey Med Sch, Newark Nj
Graduation Year: 1950

Data Provided By:
John Thomas Hocker, MD
(302) 731-9225
4745 Ogletown Stanton Rd Ste 225
Newark, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Ks Sch Of Med, Kansas City Ks 66103
Graduation Year: 1956

Data Provided By:
Alex B Bodenstab
(302) 731-2888
4745 Ogletown Stanton Rd
Newark, DE
Specialty
Orthopedic Surgery, Adult Reconstructive Orthopaedic Surgery

Data Provided By:
John R Fisher
(302) 623-4144
4735 Ogletown Stanton Rd
Newark, DE
Specialty
Orthopaedic Surgery of the Spine

Data Provided By:
Bruce Jay Rudin, MD
(302) 731-2888
4745 Ogletown Stanton Rd Ste 225
Newark, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: A Einstein Coll Of Med Of Yeshiva Univ, Bronx Ny 10461
Graduation Year: 1987

Data Provided By:
Dr.J FISHER
4735 Ogletown Stanton Road #1204
Newark, DE
Gender
M
Speciality
Orthopedic Surgeon
General Information
Accepting New Patients: Yes
RateMD Rating
5.0, out of 5 based on 1, reviews.

Data Provided By:
Bruce Edward Katz, MD
(302) 731-2888
4745 Ogletown-Stanton Rd Medical Arts Pav 1 Ste 23
Newark, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: George Washington Univ Sch Of Med & Hlth Sci, Washington Dc 20037
Graduation Year: 1991
Hospital
Hospital: St Francis Hosp, Wilmington, De; Christiana Care -Wilmington, Wilmington, De
Group Practice: First State Orthopaedic

Data Provided By:
Dr.William Newcomb
(302) 731-2888
4745 Ogletown Stanton Rd # 225
Newark, DE
Gender
M
Education
Medical School: Temple Univ Sch Of Med
Year of Graduation: 1969
Speciality
Orthopedic Surgeon
General Information
Accepting New Patients: Yes
RateMD Rating
5.0, out of 5 based on 2, reviews.

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Biologic Therapies for Aging Discs

The lines and wrinkles on our faces aren't the only signs of the inevitable aging process. Progressive degenerative changes have also been documented in the spine. One of the areas of great interest is the intervertebral disc . New biologic therapies for aging discs are the subject of this review article on the topic.

There are 33 vertebrae or spinal bones. Between each vertebra is a disc made of tough cartilage with a fluid center. These discs provide the cushion that allows your backbone to bend and twist. Discs also act like shock absorbers as we walk, run, and jump. Each vertebral segment consists of bone next to bone with a cartilage cushion between. They are tied together with connective tissue, ligaments, and tendons.

Degenerative disc disease is an example of something that affects most people as they get older. Everyone is going to have a certain amount of damage to the spine. This occurs throughout a lifetime. The discs can flatten, and protrude from between the bones. In time, most people will have small tears in the outer layers of these discs.

Finding ways to repair damage to the discs is the focus of many research studies. One of the most recent directions in research has been the use of biologic therapies to restore the disc. Examples of these treatment approaches include disc cell reimplantation, stem cell implantation, disc denervation, injection of therapeutic proteins, and gene therapy.

What are these therapies and how do they work? Biologic therapies of this type are meant to help at the cellular level. Scientists have shown that inside the cells of the disc there is a limited amount of blood flow. As a result, there are waste products building up. The cell becomes very acidic and that is a harsh environment that doesn't support cell health very well.

As we age, there are fewer new cells to replace the old. Fluid leaks out of the discs that never gets replaced. We start to lose the strength of the discs needed to cushion and support the spine. A loss of disc height can lead to disc space collapse.

That's what's happening on the inside at the cellular level. On the outside, the affected individual may not feel anything until the degenerative process has gone on quite a while. Eventually, back pain, loss of motion, and loss of function get our attention. By then, there may not be much that can be done to save the disc. Right now, surgery to remove the disc is often the only option.

That could change if any of these biologic therapies can be perfected. Right now they are still in the experimental stages. Most of the studies have been done on animals but a few human trials have been conducted.

For example, disc tissue reimplantation is a process in which a few healthy cells are removed from an intact disc. They are taken to a lab where they can be multiplied and then reinjected into the diseased disc. The hope is that the new, healthy cells will replace the damaged cells and restore the strength of t...

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