Biologic Therapies for Aging Discs Newport RI

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Edwin J Madden, MD
(401) 739-6100
91 Washington St
Newport, RI
Specialties
Orthopedics
Gender
Male
Education
Graduation Year: 2007

Data Provided By:
Dr.James Maher
(401) 849-6868
19 Friendship Street
Newport, RI
Gender
M
Speciality
Orthopedic Surgeon
General Information
Accepting New Patients: Yes
RateMD Rating
5.0, out of 5 based on 1, reviews.

Data Provided By:
Michael Patrick Staebler
(401) 842-0555
345 Valley Rd
Middletown, RI
Specialty
Orthopedic Surgery, Sports Medicine

Data Provided By:
Edwin Gerhardt Singsen, MD
(401) 846-0848
35 Powel Ave
Newport, RI
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Vt Coll Of Med, Burlington Vt 05405
Graduation Year: 1971

Data Provided By:
Bruce Derbyshire, MD
Adamsville, RI
Specialties
Orthopedics
Gender
Male
Education
Graduation Year: 2007

Data Provided By:
Elie Joseph Cohen, MD
(401) 849-6446
136 Rhode Island Ave
Newport, RI
Specialties
Orthopedics
Gender
Male
Languages
French, Arabic
Education
Medical School: Ibrahim Pasha Univ, Fac Of Med, Cairo, Egypt (915-01 After 1/1971)
Graduation Year: 1955
Hospital
Hospital: Newport Hospital, Newport, Ri
Group Practice: Elie Cohen Inc

Data Provided By:
Elie Joseph Cohen
(401) 849-6446
136 Rhode Island Ave
Newport, RI
Specialty
Orthopedic Surgery

Data Provided By:
Dennis Edward Jones, MD
(401) 842-0555
345 Valley Rd
Middletown, RI
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Ct Sch Of Med, Farmington Ct 06032
Graduation Year: 1990

Data Provided By:
Robert Joseph Cronin, MD
(401) 848-0478
27 Pequot Ln
Middletown, RI
Specialties
Orthopedics
Gender
Male
Education
Medical School: Tufts Univ Sch Of Med, Boston Ma 02111
Graduation Year: 1968

Data Provided By:
Mark A Coppes
(401) 789-1422
1 High St
Wakefield, RI
Specialty
Orthopedic Surgery

Data Provided By:
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Biologic Therapies for Aging Discs

The lines and wrinkles on our faces aren't the only signs of the inevitable aging process. Progressive degenerative changes have also been documented in the spine. One of the areas of great interest is the intervertebral disc . New biologic therapies for aging discs are the subject of this review article on the topic.

There are 33 vertebrae or spinal bones. Between each vertebra is a disc made of tough cartilage with a fluid center. These discs provide the cushion that allows your backbone to bend and twist. Discs also act like shock absorbers as we walk, run, and jump. Each vertebral segment consists of bone next to bone with a cartilage cushion between. They are tied together with connective tissue, ligaments, and tendons.

Degenerative disc disease is an example of something that affects most people as they get older. Everyone is going to have a certain amount of damage to the spine. This occurs throughout a lifetime. The discs can flatten, and protrude from between the bones. In time, most people will have small tears in the outer layers of these discs.

Finding ways to repair damage to the discs is the focus of many research studies. One of the most recent directions in research has been the use of biologic therapies to restore the disc. Examples of these treatment approaches include disc cell reimplantation, stem cell implantation, disc denervation, injection of therapeutic proteins, and gene therapy.

What are these therapies and how do they work? Biologic therapies of this type are meant to help at the cellular level. Scientists have shown that inside the cells of the disc there is a limited amount of blood flow. As a result, there are waste products building up. The cell becomes very acidic and that is a harsh environment that doesn't support cell health very well.

As we age, there are fewer new cells to replace the old. Fluid leaks out of the discs that never gets replaced. We start to lose the strength of the discs needed to cushion and support the spine. A loss of disc height can lead to disc space collapse.

That's what's happening on the inside at the cellular level. On the outside, the affected individual may not feel anything until the degenerative process has gone on quite a while. Eventually, back pain, loss of motion, and loss of function get our attention. By then, there may not be much that can be done to save the disc. Right now, surgery to remove the disc is often the only option.

That could change if any of these biologic therapies can be perfected. Right now they are still in the experimental stages. Most of the studies have been done on animals but a few human trials have been conducted.

For example, disc tissue reimplantation is a process in which a few healthy cells are removed from an intact disc. They are taken to a lab where they can be multiplied and then reinjected into the diseased disc. The hope is that the new, healthy cells will replace the damaged cells and restore the strength of t...

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