Biologic Therapies for Aging Discs Wilmington DE

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David T Sowa, MD
(302) 731-2888
4745 Ogletown Stanton Rd
Newark, DE
Business
First State Orthopaedics PA
Specialties
Orthopedics

Data Provided By:
Candice Pfeiffer Holden, MD
(302) 658-1955
2612 W 18th St
Wilmington, DE
Specialties
Orthopedics
Gender
Female
Education
Medical School: Univ Of Southern Ca Sch Of Med, Los Angeles Ca 90033
Graduation Year: 1995
Hospital
Hospital: St Christophers Hosp For Child, Philadelphia, Pa

Data Provided By:
Dr.Errol Ger
(302) 427-2370
1207 N Scott St # 4
Wilmington, DE
Gender
M
Education
Medical School: Univ Of Cape Town, Fac Of Med, Cape Town
Year of Graduation: 1966
Speciality
Orthopedic Surgeon
General Information
Accepting New Patients: Yes
RateMD Rating
5.0, out of 5 based on 1, reviews.

Data Provided By:
James Richard Bowen, MD
(302) 651-5723
PO Box 269
Wilmington, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Med Univ Of Sc Coll Of Med, Charleston Sc 29425
Graduation Year: 1971

Data Provided By:
Dan Edison Mason, MD
(302) 651-5922
PO Box 269
Wilmington, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Med Coll Of Ga Sch Of Med, Augusta Ga 30912
Graduation Year: 1971

Data Provided By:
Richard I Clemmer Jr, MD
2401 Pennsylvania Ave
Wilmington, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Jefferson Med Coll-Thos Jefferson Univ, Philadelphia Pa 19107
Graduation Year: 1971

Data Provided By:
Charles Joseph Veith, DMD
(302) 658-7354
2300 Pennsylvania Ave
Wilmington, DE
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Peter B Gabos, MD
(302) 651-5740
PO Box 269
Wilmington, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: New York Univ Sch Of Med, New York Ny 10016
Graduation Year: 1991

Data Provided By:
S Jayakumar, MD
(302) 651-5911
PO Box 269
Wilmington, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Madras Med Coll, Dr M G R Med Univ, Madras, Tn, India
Graduation Year: 1959

Data Provided By:
Ronald Michael Repice, MD
(610) 874-1500
1010 Concord Ave
Wilmington, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Hahnemann Univ Sch Of Med, Philadelphia Pa 19102
Graduation Year: 1965

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Biologic Therapies for Aging Discs

The lines and wrinkles on our faces aren't the only signs of the inevitable aging process. Progressive degenerative changes have also been documented in the spine. One of the areas of great interest is the intervertebral disc . New biologic therapies for aging discs are the subject of this review article on the topic.

There are 33 vertebrae or spinal bones. Between each vertebra is a disc made of tough cartilage with a fluid center. These discs provide the cushion that allows your backbone to bend and twist. Discs also act like shock absorbers as we walk, run, and jump. Each vertebral segment consists of bone next to bone with a cartilage cushion between. They are tied together with connective tissue, ligaments, and tendons.

Degenerative disc disease is an example of something that affects most people as they get older. Everyone is going to have a certain amount of damage to the spine. This occurs throughout a lifetime. The discs can flatten, and protrude from between the bones. In time, most people will have small tears in the outer layers of these discs.

Finding ways to repair damage to the discs is the focus of many research studies. One of the most recent directions in research has been the use of biologic therapies to restore the disc. Examples of these treatment approaches include disc cell reimplantation, stem cell implantation, disc denervation, injection of therapeutic proteins, and gene therapy.

What are these therapies and how do they work? Biologic therapies of this type are meant to help at the cellular level. Scientists have shown that inside the cells of the disc there is a limited amount of blood flow. As a result, there are waste products building up. The cell becomes very acidic and that is a harsh environment that doesn't support cell health very well.

As we age, there are fewer new cells to replace the old. Fluid leaks out of the discs that never gets replaced. We start to lose the strength of the discs needed to cushion and support the spine. A loss of disc height can lead to disc space collapse.

That's what's happening on the inside at the cellular level. On the outside, the affected individual may not feel anything until the degenerative process has gone on quite a while. Eventually, back pain, loss of motion, and loss of function get our attention. By then, there may not be much that can be done to save the disc. Right now, surgery to remove the disc is often the only option.

That could change if any of these biologic therapies can be perfected. Right now they are still in the experimental stages. Most of the studies have been done on animals but a few human trials have been conducted.

For example, disc tissue reimplantation is a process in which a few healthy cells are removed from an intact disc. They are taken to a lab where they can be multiplied and then reinjected into the diseased disc. The hope is that the new, healthy cells will replace the damaged cells and restore the strength of t...

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