Cell Therapy for Cartilage Repair Anchorage AK

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William M Dotson, DDS
(907) 563-2828
3401 Denali St Ste 203
Anchorage, AK
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Davis Cory Peterson, MD
(907) 563-3145
3260 Providence Dr Ste 200
Anchorage, AK
Specialties
Orthopedics
Gender
Male
Languages
Spanish
Education
Medical School: Baylor Coll Of Med, Houston Tx 77030
Graduation Year: 1980
Hospital
Hospital: Alaska Reg Hosp, Anchorage, Ak; Providence Alaska Med Ctr, Anchorage, Ak
Group Practice: Anchorage Fracture Clinic

Data Provided By:
William J Mills, MD
(907) 562-2277
1544 Hidden Ln
Anchorage, AK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Stanford Univ Sch Of Med, Stanford Ca 94305
Graduation Year: 1950

Data Provided By:
Robert Wm Lipke, MD
(907) 229-5363
Anchorage, AK
Gender
Male
Education
Medical School: Or Hlth Sci Univ Sch Of Med, Portland Or 97201
Graduation Year: 1972

Data Provided By:
Ronald Charles Brockman, DO
4200 Lake Otis Pkwy Ste 303
Anchorage, AK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Hlth Sci, Coll Of Osteo Med, Kansas City Mo 64124
Graduation Year: 1972

Data Provided By:
Davis C Peterson
(907) 563-3145
3260 Providence Dr
Anchorage, AK
Specialty
Orthopaedic Surgery of the Spine

Data Provided By:
William Andrew Paton, MD
(907) 729-1615
4315 Diplomacy Dr
Anchorage, AK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Case Western Reserve Univ Sch Of Med, Cleveland Oh 44106
Graduation Year: 1969

Data Provided By:
John Paul Dittrich, MD
(907) 561-1436
3340 Providence Dr Ste 566
Anchorage, AK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Med Coll Of Wi, Milwaukee Wi 53226
Graduation Year: 1959

Data Provided By:
Richard Dennis Mc Evoy, MD
(907) 563-3145
3260 Providence Dr Ste 200
Anchorage, AK
Specialties
Orthopedics, Trauma Surgery
Gender
Male
Languages
Spanish
Education
Medical School: Univ Of Mn Med Sch-Minneapolis, Minneapolis Mn 55455
Graduation Year: 1976
Hospital
Hospital: Alaska Reg Hosp, Anchorage, Ak; Providence Alaska Med Ctr, Anchorage, Ak
Group Practice: Anchorage Fracture Clinic

Data Provided By:
Loren James Jensen, MD
(907) 274-2425
4100 Lake Otis Pkwy Ste 314
Anchorage, AK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Wa Sch Of Med, Seattle Wa 98195
Graduation Year: 1985

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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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