Cell Therapy for Cartilage Repair Bear DE

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David T Sowa, MD
(302) 731-2888
4745 Ogletown Stanton Rd
Newark, DE
Business
First State Orthopaedics PA
Specialties
Orthopedics

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First State Orthopaedics
Newark, DE
Specialty
Orthopaedic Sugeon

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Angelo Anthony Cairo, DDS
(302) 453-1400
220 Christiana Medical Ctr
Newark, DE
Specialties
Orthodontics/Dentofacial Orthopedics

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Dr.David Solacoff
(302) 477-0900
2600 Glasgow Ave # 104
Newark, DE
Gender
M
Education
Medical School: Johns Hopkins Univ Sch Of Med
Year of Graduation: 1993
Speciality
Orthopedic Surgeon
General Information
Hospital: Christiana Care -Wilmington, Wilmington, De
Accepting New Patients: Yes
RateMD Rating
2.8, out of 5 based on 2, reviews.

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Victor Ray Kalman, DO
2600 Glasgow Ave
Newark, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Philadelphia Coll Of Osteo Med, Philadelphia Pa 19131
Graduation Year: 1986

Data Provided By:
Jerry Lee Case
(302) 368-5500
430 Christiana Medical Ctr
Newark, DE
Specialty
Orthopedic Surgery

Data Provided By:
Ali S Husain, DDS
(609) 838-1400
1400 Peoples Plz Ste 312
Newark, DE
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Randeep Kahlon, MD
Newark, DE
Specialty
Orthopaedic Sugeon

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David Kenan Solacoff, MD
(302) 832-6220
2600 Glasgow Ave Ste 104
Newark, DE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Johns Hopkins Univ Sch Of Med, Baltimore Md 21205
Graduation Year: 1993
Hospital
Hospital: Christiana Care -Wilmington, Wilmington, De
Group Practice: Casscells Orthopedics

Data Provided By:
Jerry L Case, MD
(302) 368-5500
430 Christiana Medical Ctr
Newark, DE
Specialties
Orthopedics, Legal Medicine
Gender
Male
Education
Medical School: Univ Of Ia Coll Of Med, Iowa City Ia 52242
Graduation Year: 1960
Hospital
Hospital: Christiana Care -Wilmington, Wilmington, De

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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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