Cell Therapy for Cartilage Repair Boise ID

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Jeffry Paul Menzner, MD
(208) 323-2600
1075 N Curtis Rd Ste 300
Boise, ID
Specialties
Orthopedics
Gender
Male
Education
Medical School: Baylor Coll Of Med, Houston Tx 77030
Graduation Year: 1990

Data Provided By:
Dr.Kevin Shea
(208) 383-0201
600 W Robbins Rd # 100
Boise, ID
Gender
M
Speciality
Orthopedic Surgeon
General Information
Hospital: St. Lukes
Accepting New Patients: Yes
RateMD Rating
5.0, out of 5 based on 1, reviews.

Data Provided By:
Mary Elizabeth Reid, MD
Boise, ID
Specialties
Orthopedics
Gender
Female
Education
Medical School: Univ Of Al Sch Of Med, Birmingham Al 35294
Graduation Year: 1985

Data Provided By:
John Kalange, DDS
(208) 342-0212
136 E Mallard Dr
Boise, ID
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Kirk J Lewis
(208) 336-8250
1188 University Dr
Boise, ID
Specialty
Orthopedic Surgery, Sports Medicine

Data Provided By:
Loren David Blickenstaff, MD
4215 Country Club Dr
Boise, ID
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Ks Sch Of Med, Kansas City Ks 66103
Graduation Year: 1956

Data Provided By:
Colin E Poole, MD
(208) 383-0201
600 Robbins Rd Ste 401
Boise, ID
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Cape Town, Fac Of Med, Cape Town, So Africa
Graduation Year: 1991

Data Provided By:
Dennis Raibourn Mc Gee, MD
(208) 383-0201
600 Robbins Rd Ste 401
Boise, ID
Specialties
Orthopedics
Gender
Male
Education
Medical School: In Univ Sch Of Med, Indianapolis In 46202
Graduation Year: 1982
Hospital
Hospital: St Lukes Reg Medctr, Boise, Id
Group Practice: Intermountain Orthopaedics

Data Provided By:
Joseph Gordon Daines
(208) 378-2868
901 N Curtis Rd
Boise, ID
Specialty
Orthopedic Surgery

Data Provided By:
Jeffrey Glenn Hessing, MD
(208) 321-4790
901 N Curtis Rd Ste 501
Boise, ID
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Wa Sch Of Med, Seattle Wa 98195
Graduation Year: 1980

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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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