Cell Therapy for Cartilage Repair Brattleboro VT

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Donald Leslie Kinley, MD
(802) 254-9441
PO Box 656
Brattleboro, VT
Specialties
Orthopedics
Gender
Male
Education
Medical School: Mc Gill Univ, Fac Of Med, Montreal, Que, Canada
Graduation Year: 1964

Data Provided By:
William Vranos
(802) 254-6211
17 Belmont Ave
Brattleboro, VT
Specialty
Orthopedic Surgery

Data Provided By:
Jonathan Charles Thatcher
(802) 254-3500
17 Belmont Ave
Brattleboro, VT
Specialty
Orthopedic Surgery

Data Provided By:
Elizabeth Ann McLarney
(802) 254-7787
17 Belmont Avenue
Brattleboro, VT
Specialty
Orthopedic Surgery, Adult Reconstructive Orthopaedic Surgery

Data Provided By:
Cherie A Holmes
(603) 354-5482
590 Court Street
Keene, NH
Specialty
Orthopedic Surgery

Data Provided By:
Elizabeth Ann McLarney, MD
(802) 254-7787
17 Belmont Ave
Brattleboro, VT
Specialties
Orthopedics, Sports Medicine-Family Practice
Gender
Female
Education
Medical School: Albany Med Coll, Albany Ny 12208
Graduation Year: 1992
Hospital
Hospital: Brattleboro Mem Hosp, Brattleboro, Vt

Data Provided By:
Jonathan Charles Thatcher, MD
17 Belmont Ave
Brattleboro, VT
Specialties
Orthopedics
Gender
Male
Education
Medical School: Boston Univ Sch Of Med, Boston Ma 02118
Graduation Year: 1982

Data Provided By:
Dr.Elizabeth McLarney
(802) 254-7787
17 Belmont Ave # 1051
Brattleboro, VT
Gender
F
Education
Medical School: Albany Med Coll
Year of Graduation: 1992
Speciality
Orthopedic Surgeon
General Information
Hospital: Brattleboro Mem Hosp, Brattleboro, Vt
Accepting New Patients: Yes
RateMD Rating
4.5, out of 5 based on 3, reviews.

Data Provided By:
Harold Roger Hansen, MD
(603) 354-5400
Spofford, NH
Specialties
Orthopedics
Gender
Male
Education
Medical School: Jefferson Med Coll-Thos Jefferson Univ, Philadelphia Pa 19107
Graduation Year: 1969

Data Provided By:
Paul C Bettinger, MD
603-354-5454 x3563
590 Court St
Keene, NH
Specialties
Orthopedics, Hand Surgery
Gender
Male
Education
Medical School: Tufts Univ Sch Of Med, Boston Ma 02111
Graduation Year: 1989

Data Provided By:
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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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