Cell Therapy for Cartilage Repair Chaska MN

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Michael H Hoxie, DDS
(952) 937-0111
2634 Shadow Ln
Chaska, MN
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Gordon Alvin Welke, MD
(952) 931-9718
Chanhassen, MN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Saskatchewan, Coll Of Med, Saskatoon, Sask, Canada
Graduation Year: 1979
Hospital
Hospital: Fairmont Comm Hosp, Fairmont, Mn
Group Practice: Fairmont Medical Center Mayo Health System; Orthopedic Consultants Chaska Health Center

Data Provided By:
Darren F Larson
(952) 993-7800
1415 Saint Francis Ave
Shakopee, MN
Specialty
Orthopedic Surgery

Data Provided By:
Dean Curtis Taylor, MD
(952) 831-8742
Victoria, MN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Duke Univ Sch Of Med, Durham Nc 27710
Graduation Year: 1985

Data Provided By:
Paul G Dworak, MD
(952) 832-0076
10984 Chapman Pointe
Eden Prairie, MN
Specialties
Orthopedics
Gender
Male
Education
Graduation Year: 2007

Data Provided By:
Dr.Mark Wilczynski
(952) 831-8742
1415 Saint Francis Avenue #200
Shakopee, MN
Gender
M
Speciality
Orthopedic Surgeon
General Information
Hospital: Park Nicollet
Accepting New Patients: Yes
RateMD Rating
1.0, out of 5 based on 1, reviews.

Data Provided By:
Mark Conrad Gregerson, MD
(952) 403-3399
1515 Saint Francis Ave Ste 150
Shakopee, MN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Nd Sch Of Med, Grand Forks Nd 58201
Graduation Year: 1981

Data Provided By:
Joseph Alan Fiedler, DDS
(952) 934-0103
470 W 78th St Ste 200
Chanhassen, MN
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Bruce W Hultgren, DDS
(952) 937-0111
7825 Terrey Pine Ct Ste 101
Eden Prairie, MN
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Michael Richard Walsh, MD
(952) 941-5721
Eden Prairie, MN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Mn Med Sch-Minneapolis, Minneapolis Mn 55455
Graduation Year: 1998

Data Provided By:
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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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