Cell Therapy for Cartilage Repair Chickasha OK

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Jack Juan Beller
(405) 224-2100
2100 W Iowa Ave
Chickasha, OK
Specialty
Orthopedic Surgery, Sports Medicine

Data Provided By:
Robert Charles Lesher, MD
(405) 224-0109
Chickasha, OK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Hahnemann Univ Sch Of Med, Philadelphia Pa 19102
Graduation Year: 1959

Data Provided By:
Bommasamudram Ashwini Kumar
(405) 224-2100
2100 W Iowa Ave
Chickasha, OK
Specialty
Orthopedic Surgery, Sports Medicine

Data Provided By:
Harvey C Jenkins Jr., MD
(405) 686-1700
8603 S Western Ave
Oklahoma City, OK
Business
Aria Orthopedics
Specialties
Orthopedics

Data Provided By:
Steven C Anagnost, MD
(918) 582-6800
1809 E 13th St Ste 100
Tulsa, OK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Tn, Memphis, Coll Of Med, Memphis Tn 38163
Graduation Year: 1993

Data Provided By:
Lee Vander Lugt, DO
(405) 222-9589
2222 W Iowa Ave
Chickasha, OK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Kirksville Coll Of Osteo Med, Kirksville Mo 63501
Graduation Year: 1972
Hospital
Hospital: Grady Memorial Hospital, Chickasha, Ok
Group Practice: Southern Plains Medical Center

Data Provided By:
Lee Vanderlugt
(405) 224-8111
2222 W Iowa Ave
Chickasha, OK
Specialty
Orthopedic Surgery

Data Provided By:
Dr.Jack Beller
(405) 224-2100
2100 West Iowa Avenue
Chickasha, OK
Gender
M
Speciality
Orthopedic Surgeon
General Information
Hospital: Grady County Memorial Hospital
Accepting New Patients: Yes
RateMD Rating
1.2, out of 5 based on 3, reviews.

Data Provided By:
Richard Don James, DDS
(405) 848-2884
3621 Nw 63Rd St
Oklahoma City, OK
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Stephen Tkach, MD
405-232-0341 x404
1110 N Lee Ave
Oklahoma City, OK
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Ks Sch Of Med, Kansas City Ks 66103
Graduation Year: 1960
Hospital
Hospital: St Anthony Hospital, Oklahoma City, Ok; Bone & Joint Hosp, Oklahoma City, Ok
Group Practice: Mc Bride Clinic Inc

Data Provided By:
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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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