Cell Therapy for Cartilage Repair Madison TN

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Lloyd Alexis Walwyn, MD
(615) 865-1616
601 W Due West Ave
Madison, TN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Howard Univ Coll Of Med, Washington Dc 20059
Graduation Year: 1967

Data Provided By:
Marion G Doyle, DMD
(615) 865-9400
624 W Due West Ave Ste 120
Madison, TN
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Jane Meredith Siegel, MD
(615) 329-6600
3443 Dickerson Pike
Nashville, TN
Specialties
Orthopedics, Hand Surgery
Gender
Female
Education
Medical School: Vanderbilt Univ Sch Of Med, Nashville Tn 37232
Graduation Year: 1988

Data Provided By:
Calvin Robinson Dyer
(615) 263-6500
3443 Dickerson Pike
Nashville, TN
Specialty
Orthopedic Surgery, Sports Medicine

Data Provided By:
Steve G Salyers
(615) 860-1580
3443 Dickerson Pike
Nashville, TN
Specialty
Orthopedic Surgery, Sports Medicine

Data Provided By:
Lawrence Brett Babat, MD
(615) 860-1580
3443 Dickerson Pike Ste 190
Nashville, TN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Yale Univ Sch Of Med, New Haven Ct 06510
Graduation Year: 1995

Data Provided By:
Steven G McLaughlin
(615) 860-1580
3443 Dickerson Pike
Nashville, TN
Specialty
Orthopedic Surgery

Data Provided By:
Philip G Krewer, MD
665 Myatt Dr
Madison, TN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Southern Ca Sch Of Med, Los Angeles Ca 90033
Graduation Year: 1995

Data Provided By:
Gary David Rubin, MD
500 Hospital Dr
Madison, TN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Southern Il Univ Sch Of Med, Springfield Il 62794
Graduation Year: 1982

Data Provided By:
Alan Stuart Henson, MD
(615) 865-1337
510 Hospital Dr Ste 100
Madison, TN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Mi State Univ Coll Of Human Med, East Lansing Mi 48824
Graduation Year: 1977

Data Provided By:
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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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