Cell Therapy for Cartilage Repair Marion NC

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George Cameron Green, MD
(828) 652-1673
60 S Medical Ct
Marion, NC
Specialties
Orthopedics
Gender
Male
Education
Medical School: Tulane Univ Sch Of Med, New Orleans La 70112
Graduation Year: 1981

Data Provided By:
Stanley Craig Topple, MD
(828) 664-1888
PO Box 5
Montreat, NC
Specialties
Orthopedics
Gender
Male
Education
Medical School: Emory Univ Sch Of Med, Atlanta Ga 30322
Graduation Year: 1957

Data Provided By:
Henry D Wilde, MD
(713) 986-5510
Montreat, NC
Specialties
Orthopedics
Gender
Male
Education
Graduation Year: 2007

Data Provided By:
Russell Austin Flint, MD
(828) 765-8200
78 Broad St
Spruce Pine, NC
Specialties
Orthopedics
Gender
Male
Education
Medical School: Emory Univ Sch Of Med, Atlanta Ga 30322
Graduation Year: 1987
Hospital
Hospital: Spruce Pine Community Hospital, Spruce Pine, Nc

Data Provided By:
Steven Sungho Lee, MD
105 Castlegate Dr
Morganton, NC
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Ca, San Diego, Sch Of Med, La Jolla Ca 92093
Graduation Year: 1998

Data Provided By:
Russell Austin Flint
(828) 765-8200
78 Broad St
Spruce Pine, NC
Specialty
Orthopedic Surgery

Data Provided By:
William Singleton Ogden, MD
(662) 332-8700
Montreat, NC
Specialties
Orthopedics
Gender
Male
Education
Medical School: Med Coll Of Ga Sch Of Med, Augusta Ga 30912
Graduation Year: 1965

Data Provided By:
Dr.Russell Flint
(828) 765-8200
78 Broad Street
Spruce Pine, NC
Gender
M
Education
Medical School: Emory Univ Sch Of Med
Year of Graduation: 1987
Speciality
Orthopedic Surgeon
General Information
Hospital: Spruce Pine Community Hospital, Spruce Pine, Nc
Accepting New Patients: Yes
RateMD Rating
5.0, out of 5 based on 1, reviews.

Data Provided By:
Robert Alan Miller
(828) 765-8200
78 Broad St
Spruce Pine, NC
Specialty
Orthopedic Surgery

Data Provided By:
Mark S Brazinski
(828) 437-8648
503 E Parker Rd
Morganton, NC
Specialty
Orthopedic Surgery

Data Provided By:
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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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