Cell Therapy for Cartilage Repair Midlothian VA

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Paul George Kiritsis
(804) 379-2414
13700 Saint Francis Blvd
Midlothian, VA
Specialty
Adult Reconstructive Orthopaedic Surgery

Data Provided By:
Richard H Lee, DMD
(804) 379-2205
14267 Midlothian Tpke
Midlothian, VA
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Dale Cole Rogers, DDS
(804) 794-9789
1600 Huguenot Rd
Midlothian, VA
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
John Donald Zachary, MD
1521 Huguenot Rd
Midlothian, VA
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Chicago, Pritzker Sch Of Med, Chicago Il 60637
Graduation Year: 1967
Hospital
Hospital: Deaconess Hosp Of Cleveland, Cleveland, Oh

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David Wayne Miller, MD
(804) 560-5595
Midlothian, VA
Specialties
Orthopedics
Gender
Male
Education
Medical School: Georgetown Univ Sch Of Med, Washington Dc 20007
Graduation Year: 1988

Data Provided By:
Mark H Hadfield
(804) 379-2414
13700 St Francis Blvd
Midlothian, VA
Specialty
Adult Reconstructive Orthopaedic Surgery

Data Provided By:
Harry Albert Raddin, DDS
(804) 745-0100
13841 Hull St Rd Ste 3
Midlothian, VA
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
John W King, DDS
(804) 739-3399
5921 Harbour Ln Ste 300
Midlothian, VA
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Charles William Dabney, DDS
(804) 794-8943
13321 Midlothian Tpke Ste A
Midlothian, VA
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Thomas E Spillers, DDS
(804) 897-8600
1403 Huguenot Rd Ste 100
Midlothian, VA
Specialties
Orthodontics/Dentofacial Orthopedics

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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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