Cell Therapy for Cartilage Repair North Platte NE

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Peter B Brassard, MD
(308) 534-6655
611 W Francis St Ste 290
North Platte, NE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Georgetown Univ Sch Of Med, Washington Dc 20007
Graduation Year: 1971

Data Provided By:
John David Hannah, MD
(308) 534-6655
611 W Francis St Ste 290
North Platte, NE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Loma Linda Univ Sch Of Med, Loma Linda Ca 92350
Graduation Year: 1993

Data Provided By:
John W Haugen, DDS
(308) 534-1783
611 W Francis St # 230
North Platte, NE
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Dennis P McGowan, MD
(308) 237-0889
1215 First Ave
Kearney, NE
Business
Dennis P McGowan MD
Specialties
Orthopedics

Data Provided By:
Morris Fredrick Skinner, MD
(619) 232-0300
938 E Zero St
Ainsworth, NE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Ne Coll Of Med, Omaha Ne 68198
Graduation Year: 1958

Data Provided By:
Mark Kimball Mc Kenzie, MD
(308) 534-6655
3000 W Leota St
North Platte, NE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Sd Sch Of Med, Vermillion Sd, 57069
Graduation Year: 1986

Data Provided By:
Benjamin Bissell, MD
North Platte, NE
Specialty
Orthopaedic Sugeon

Data Provided By:
Benjamin Bissell, MD
(308) 534-6655
215 McNeel Lane
North Platte, NE
Specialty
Orthopedic Surgeon, Sports Medicine

Richard Philip Holm, MD
(757) 562-6633
300 N 2nd St
Oneill, NE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Wa Sch Of Med, Seattle Wa 98195
Graduation Year: 1979

Data Provided By:
Jonathan Ellis Fuller, MD
(402) 496-0404
11819 Miracle Dr
Omaha, NE
Specialties
Orthopedics
Gender
Male
Education
Medical School: Columbia Univ Coll Of Physicians And Surgeons, New York Ny 10032
Graduation Year: 1987

Data Provided By:
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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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