Cell Therapy for Cartilage Repair Peru IN

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William Hugo Pohnert, MD
(765) 472-8041
285 W 12th St Ste 106
Peru, IN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Mi Med Sch, Ann Arbor Mi 48109
Graduation Year: 1967
Hospital
Hospital: Howard Comm Hosp, Kokomo, In; St Joseph Mem Hosp, Kokomo, In; Dukes Mem Hosp, Peru, In; Healthsouth Rehabilitation Hos, Kokomo, In
Group Practice: Northcentral Indiana Ortho

Data Provided By:
Jesse Lee Sandlin, MD
(574) 753-4193
1601 Chase Rd
Logansport, IN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Northeastern Oh Univs Coll Of Med, Rootstown Oh 44272
Graduation Year: 1994

Data Provided By:
Jeffrey F Granger
(574) 753-4193
1601 Chase Rd
Logansport, IN
Specialty
Orthopedic Surgery

Data Provided By:
Charles Edward Montgomery, MD
(574) 753-4193
1601 Chase Rd
Logansport, IN
Specialties
Orthopedics
Gender
Male
Education
Medical School: In Univ Sch Of Med, Indianapolis In 46202
Graduation Year: 1969

Data Provided By:
Thomas M Reilly
(765) 236-8700
311 S Berkley Rd
Kokomo, IN
Specialty
Orthopaedic Surgery of the Spine

Data Provided By:
Aijaz Mohammed Mirza, MD
(260) 569-2408
710 N East St
Wabash, IN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Dow Med Coll, Univ Of Karachi, Karachi, Pakistan
Graduation Year: 1958
Hospital
Hospital: Wabash County Hosp, Wabash, In
Group Practice: Mirza Orthopedics

Data Provided By:
Charles E Montgomery
(574) 753-4193
1601 Chase Rd
Logansport, IN
Specialty
Orthopedic Surgery

Data Provided By:
Jeffrey Francis Granger, MD
(574) 753-4193
1601 Chase Rd
Logansport, IN
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Chicago, Pritzker Sch Of Med, Chicago Il 60637
Graduation Year: 1981

Data Provided By:
Jeffrey Dean Yoder
(765) 868-0313
1907 W Sycamore St
Kokomo, IN
Specialty
Orthopedic Surgery

Data Provided By:
Aaron Jon LeGrand
(765) 868-0313
1907 W Sycamore St
Kokomo, IN
Specialty
Orthopedic Surgery

Data Provided By:
Data Provided By:

Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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