Cell Therapy for Cartilage Repair Ridgeland MS

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Manish Arun Patel, MD
(601) 354-4488
Ridgeland, MS
Specialties
Orthopedics
Gender
Male
Education
Medical School: Allegheny Univ Of Hlth Sciences, Philadelphia Pa 19129
Graduation Year: 2000

Data Provided By:
Christopher Hans Henry, DDS
(601) 957-1711
Ridgeland, MS
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Sidney Ray Berry, MD
(601) 977-9656
446 Saint Andrews Dr
Jackson, MS
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Tn, Memphis, Coll Of Med, Memphis Tn 38163
Graduation Year: 1958
Hospital
Hospital: River Oaks Hospital, Jackson, Ms

Data Provided By:
George D Purvis, MD FACS
(601) 982-3531
2101 Eastover Dr
Jackson, MS
Gender
Male
Education
Medical School: Tennessee
Graduation Year: 1944

Data Provided By:
Lloyd Franklin M Mercer, MD
(601) 853-2351
Madison, MS
Specialties
Orthopedics
Gender
Male
Education
Medical School: Yale Univ Sch Of Med, New Haven Ct 06510
Graduation Year: 1969

Data Provided By:
Robert Kersey Mehrle Jr, MD
Ridgeland, MS
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Ms Sch Of Med, Jackson Ms 39216
Graduation Year: 1999

Data Provided By:
Jason William Levine, MD
(419) 383-6077
Ridgeland, MS
Specialties
Orthopedics
Gender
Male
Education
Medical School: Med Coll Of Ohio, Toledo Oh 43699
Graduation Year: 2000

Data Provided By:
K Noel Reed, DDS
(601) 898-8000
451 Pebble Creek Dr
Madison, MS
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Robert Shaye, DDS
(601) 984-6110
2500 N State St
Madison, MS
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
Louis Burton Guy, DDS
(601) 981-5004
4500 I 55 N Ste 247
Jackson, MS
Specialties
Orthodontics/Dentofacial Orthopedics

Data Provided By:
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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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