Cell Therapy for Cartilage Repair Waterville ME

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Lisa Beth Sauer, MD
30 Chase Ave
Waterville, ME
Specialties
Orthopedics
Gender
Female
Education
Medical School: Tufts Univ Sch Of Med, Boston Ma 02111
Graduation Year: 1985

Data Provided By:
Andre Peter Edmonds, MD
(207) 873-3700
325D Kennedy Memorial Dr
Waterville, ME
Specialties
Orthopedics, Trauma Surgery
Gender
Male
Education
Medical School: Mc Gill Univ, Fac Of Med, Montreal, Que, Canada
Graduation Year: 1976

Data Provided By:
Dr.Marc Golden
(207) 873-0200
246 Kennedy Memorial Drive #101
Waterville, ME
Gender
M
Education
Medical School: Umdnj-Sch Of Osteo Med
Year of Graduation: 1985
Speciality
Orthopedic Surgeon
General Information
Accepting New Patients: Yes
RateMD Rating
4.2, out of 5 based on 4, reviews.

Data Provided By:
Robert C Hottentot, DO
(207) 465-3683
180 Kennedy Memorial Dr Ste 30
Waterville, ME
Specialties
Orthopedics
Gender
Male
Education
Medical School: Mi State Univ, Coll Of Osteo Med, East Lansing Mi 48824
Graduation Year: 1976

Data Provided By:
Vaughn Morgan Collett, MD
246 Kennedy Memorial Dr
Waterville, ME
Specialties
Orthopedics
Gender
Male
Education
Medical School: Mem Univ Of Newfoundland, Fac Of Med, St Johns, Nfld, Canada
Graduation Year: 1993

Data Provided By:
James Fenwick Butler III, MD
325C Kennedy Memorial Dr
Waterville, ME
Specialties
Orthopedics
Gender
Male
Education
Medical School: Univ Of Vt Coll Of Med, Burlington Vt 05405
Graduation Year: 1965

Data Provided By:
Catherine E Meikle, MD
(207) 873-1329
325D Kennedy Memorial Dr
Waterville, ME
Specialties
Orthopedics
Gender
Female
Education
Medical School: Cornell Univ Med Coll, New York Ny 10021
Graduation Year: 1984

Data Provided By:
Marc Steven Golden, DO
(207) 873-0200
246 Kennedy Memorial Dr
Waterville, ME
Specialties
Orthopedics
Gender
Male
Education
Medical School: Umdnj-Sch Of Osteo Med, Stratford Nj 08084
Graduation Year: 1985

Data Provided By:
Jose Antonio Ramirez, MD
(207) 873-6009
325E Kennedy Memorial Dr
Waterville, ME
Specialties
Orthopedics
Gender
Male
Education
Medical School: Oh State Univ Coll Of Med, Columbus Oh 43210
Graduation Year: 1982

Data Provided By:
Albert Joseph Pepe, MD
(207) 465-7436
69 County Rd
Oakland, ME
Specialties
Orthopedics
Gender
Male
Education
Medical School: New York Univ Sch Of Med, New York Ny 10016
Graduation Year: 1966

Data Provided By:
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Cell Therapy for Cartilage Repair: A Review and Update

Research into repair techniques for damage to knee cartilage is moving right along. Surgeons in Europe and Australia are ahead of American surgeons as they have moved from first-generation cartilage repair through second generation methods to the more current third-generation approaches.

Only one type of third-generation cell therapy for cartilage repair is available in the United States: the matrix-induced autologous chondrocyte implantation or MACI. MACI is the subject of this review article. Although it is being used by U.S. surgeons, the U.S. Food and Drug Administration (FDA) has not yet approved this type of cell carrier yet.

But let's step back a minute and get some background information that will help you understand what's going on. The basic problem is one of damage to the articular (joint surface) cartilage of the knee. The hole or defect can be small but deep (all the way down to the bone). Sometimes, the defect is large (wide and deep).

The affected person experiences knee pain and joint swelling, locking, stiffness, and clicking. The symptoms can be bad enough to interfere with daily activities at home and work and create quite a bit of disability. Sports participation can be out of the question.

Because so many athletes are affected and given the fact that knee joint (articular) cartilage doesn't repair itself, researchers started looking for ways to treat cartilage injuries of this type. They tried scraping the area and smoothing it down, a procedure called debridement. They tried drilling tiny holes into the bone marrow to stimulate bone healing. That's called microfracture. And they tried taking healthy cartilage from one part of the knee and transferring it to the lesion to fill in the hole.

All of these treatment methods had problems. There wasn't one approach that could work well for all different types and sizes of cartilage defects. That's when cell therapy was developed. Healthy cartilage cells (chondrocytes) were harvested from the knee but instead of using them directly in the damaged area, they were transferred to a lab. In the lab, the cells were used to grow more cells. When there were enough cells to fill in the hole, they were reimplanted into the patient and covered with a patch made of periosteal (bone) cells.

That procedure was called autologous chondrocyte implantation (ACI). It was the first cell therapy devised for the problem of full-thickness (down to the bone) cartilage injuries. That's why it's considered a first-generation approach to cell therapy cartilage repair. But again there were problems. The procedure is invasive and requires a two-step (staged) surgical procedure. That means at least two surgeries with all of the possible costs and risks that go with staged procedures.

The next batch of autologous chondrocyte implants were improved and formed the second-generation techniques. Instead of covering the patched up hole with periosteum (bone cells), they t...

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